Erythropoietin update 2011
نویسندگان
چکیده
Traditionally, erythropoietin (EPO) is described as a hematopoietic cytokine, regulating proliferation and differentiation and survival of the erythroid progenitors. The recent finding of new sites of EPO production and the wide spread distribution of EPO receptors (EPO-R) on endothelial cells, cardiomyocytes, renal cells as well as the central and peripheral nervous system raised the possibility that EPO may exert pleiotropic actions on several targets. Indeed studies (mainly preclinical) have documented protective, non-hematopoietic, abilities of EPO in a variety of tissue. However, the data obtained from clinical studies are more skeptical about these properties. This article provides a comprehensive overview of EPO and its derivatives.
منابع مشابه
An Update on the Controversies in Anemia Management in Chronic Kidney Disease: Lessons Learned and Lost
Background. Erythropoietin deficiency and anemia occur in Chronic Kidney Disease (CKD) and may be treated with Erythropoietin Stimulating Agents (ESAs). The optimal hemoglobin, in non-End Stage Renal Disease CKD, is controversial. Methods. We review three recent randomized trials in anemia in CKD: CHOIR, CREATE, and TREAT. Results. CHOIR (N = 1432) was terminated early with more frequent death ...
متن کاملThe Effect of Early Subcutaneous Administration of Erythropoietin on Hematopoiesis and Weight Gain Velocity in Preterm Infants
Abstract Introduction Anemia in preterm infants is identified as hemoglobin lower than 7-10g/dl around 1-3 months after birth. The aim of this study was to evaluate the effect of early subcutaneous administration of erythropoietin on hematopoiesis and weight gain velocity in preterm infants. Materials and Methods The present study was clinical trial carried out on 42 preterm infants. Those ...
متن کاملHigh glucose stimulates the expression of erythropoietin in rat glomerular epithelial cells
It has been reported that the levels of erythropoietin are associated with diabetes mellitus. Glomerular epithelial cells, located in the renal cortex, play an important role in the regulation of kidney function and hyperglycemia-induced cell loss of glomerular epithelial cells is implicated in the onset of diabetic nephropathy. This study investigated the effect of high glucose on erythropoiet...
متن کاملEffect of single recombinant human erythropoietin injection on transfusion requirements in preoperatively anemic patients undergoing valvular heart surgery.
BACKGROUND The authors investigated the effect of a single preoperative bolus of erythropoietin on perioperative transfusion requirement and erythropoiesis in patients with preoperative anemia undergoing valvular heart surgery. METHODS In this prospective, single-site, single-blinded, randomized, and parallel-arm controlled trial, 74 patients with preoperative anemia were randomly allocated t...
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عنوان ژورنال:
دوره 17 شماره
صفحات -
تاریخ انتشار 2011